ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES OF PYROSTEGIA VENUSTA PRES. STEMSAbstract
Objective: Pyrostegia venusta (Ker Gawl.) Miers, Bignoniaceae, is native to the Brazilian Cerrado and popularly known as “cipó-de-são-joão”. In Brazilian folk medicine, the flowers of P. venusta are used as a general tonic and a treatment for diarrhea, vitiligo, cough, and common infections and inflammatory diseases of the respiratory system. Nevertheless, there are still no studies on its possible anti-inflammatory and analgesic effects. Methods: The P. venusta methanolic and pet. ether extract was used to evaluate the anti-inflammatory and analgesic effects in carrageenan-induced paw edema and anti analgesic activity effect in hot plate method. Results: Stem extracts of Pyrostegia venusta demonstrated the analgesic activity at dose of 50 mg/kg body weight. At the end of one-hour percent analgesia induced by petroleum ether extract is 26.34% and that by total methanolic extract is 40.69%. The total petroleum ether extract produced 43.10% inhibition of paw edema, methanolic extract showed 54.31% inhibition of paw edema. Both the extracts had comparable activity. Conclusions: Hence it revealed that Pyrostegia venusta stem extracts had potent anti-inflammatory activity.
M. R. M. Usman * and N. Chaubey
Department of School of Pharmacy, Sri Satya Sai University of Technology and Medical Sciences, Sehore, Madhya Pradesh, India.
22 March, 2018
23 May, 2018
31 May, 2018
01 November, 2018