ANTI-ULCER EFFICACY AND SAFETY OF ANDA LEGHYAM A POLYHERBAL SIDDHA FORMULATIONAbstract
Anda leghyam (AL) a herbo-animal Siddha formulation is administered for Gunmam (Acid peptic diseases) by many Siddha physicians popularly. Anti ulcerogenic activity of the AL has been studied using Aspirin-Pylorus ligation induced gastric ulcer methods (four groups/method, n=6, Aspirin 400mg/kg, Omeprazole 10mg/kg, AL 250,500mg/kg) in wistar albino rat models. Animals were sacrificed and their stomachs were subjected to macroscopic and microscopic ulcer index findings. Statistical data were analyzed by one way ANOVA followed by student’s t-test. This study concluded that AL had significant anti-ulcer effects in experimental animals with ulcer induced by aspirin and pylorus ligation; it showed a dose dependent protection against aspirin (400 mg/kg body weight) induced ulcers in rats and it produced a significant reduction of ulcer index in the dose of 500mg/kg bodyweight. AL showed a statistically significant P value < 0.05 and <0.01 at dose level 250 mg/kg and 500 mg/kg respectively as compared to control. Acute toxicity study was carried out as per OECD guidelines and the LD50 was found to be greater than 2000mg/kg body weight with no histopathological or behavioral changes in the experimental animals.
G.J. Christian*1, H. Mubarak , K. Yamini , T. Onesimus , S. Elansekaran , K. Vennila and L. Janani
National Institute of Siddha, Autonomous Institution under Dept. of AYUSH, Ministry of Health & Family Welfare, Govt. of India,Tambaram Sanatorium, Chennai - 47, Tamil Nadu, India.
28 November, 2013
24 January, 2014
26 February, 2014
01, May 2014