ANTIBACTERIAL AND CYTOTOXIC POTENTIAL OF DALBERGIA SPINOSA ROXB. LEAVESAbstract
Dalbergia spinosa Roxb. (Leguminosae) is a mangrove plant native to Asia and enjoys number of traditional uses. This paper describes the investigation of antibacterial and cytotoxic activity of the ethanol extract of D. spinosa leaves. Antibacterial activity of the ethanol extract of D. spinosa leaves was tested by disc diffusion assay and broth macrodilution assay. The extract was also tested for brine shrimp lethality. The extract showed antibacterial activity against a wide range of Gram-positive and Gram-negative bacteria in both assays. The minimum inhibitory concentrations (MIC) against these bacteria were in the range of 250-500 μg/mL. The LC50 against brine shrimp nauplii was 84.14 μg/mL. The above data demonstrates that the plant has some important biological activities with sufficient potency and further studies can be performed to identify the active compound(s).
Sanjib Saha*, Md. Anisuzzman, Md. Khirul Islam, Himangsu Mondal and Chinmoy Talukder
Pharmacy Discipline, Life Science School, Khulna University, Khulna 9208, Bangladesh
09 September, 2012
06 November, 2012
29 December, 2012
01 January, 2013