ANTIDIARRHOEAL AND ANALGESIC ACTIVITY OF BARKS OF MEDICINAL PLANT CAESALPINIA PULCHERRIMAAbstract
The ethanolic extract of barks of Caesalpinia pulcherrima (Family- Caesalpiniaceae) was evaluated for anti-diarrhoeal and analgesic activities in animal models. The crude ethanolic extract of Caesalpinia pulcherrima showed considerable anti-diarrhoeal activity on castor oil induced diarrhoea in mice and it increased mean latent period and decreased the frequency of defecation significantly (P<0.001) at the oral dose of 500 mg/kg body weight comparable to the standard drug Loperamide at the dose of 50 mg/kg of body weight. The extract of barks also produced significant (P<0.001) writhing inhibition in acetic acid induced writhing in mice at the oral dose of 500 mg/kg body weight where writhing inhibition for the extract of barks was 47.11%, which was comparable to the standard drug Diclofenac sodium at the dose of 25 mg/kg of body weight.
T. Afroz*, S. Ramproshad , B. Mondal , A. Haque and R. Khan
Department of Pharmacy, Jahangirnagar University, Savar, Dhaka, Bangladesh
20 January, 2013
20 March, 2013
26 April, 2013
01 May, 2013