ANTIMICROBIAL ACTIVITY OF 2, 2-BIPYRIDINEDICHLOROPLATINUM (II), C10H8CL2N2PtAbstract
Antimicrobial activity of compound (2) was investigated against pathogenic microorganisms: Staphylococcus aureus (Gram (+), Escherichia coli (Gram (-) and fungal strain, Candida albicans using the Well Diffusion and the Poison plate methods. Compound (2) was shown to inhibit pathogenic growth, and judging from the area of the zone of inhibition, the susceptibility of the microorganism against compound (2) follows the sequence: Staphylococcus aureus > Candida albicans > Escherichia coli. The area of zone of inhibition ranging from (4.64 mm2 to 6.47 mm2) and (4.64mm2 to 5.72 mm2) for the Well Diffusion and Poison plates respectively. Both methods indicate that the area of the zone of inhibition for compound (2) is more potent than reference antibiotics: Nystatin and Ampicillin.
Raymond C. Jagessar * and Subramanian Gomathinayagam
Senior Lecturer, Department of Chemistry, University of Guyana, Turkeyen Campus, Georgetown, Guyana, South America
09 August, 2012
23 October, 2012
24 November, 2012
01 December, 2012