ANTIOXIDANT, CYTOTOXIC AND ANTIMICROBIAL ACTIVITY OF SONNERATIA ALBA BARK
AbstractThe present study was undertaken to evaluate antioxidant, cytotoxic and antimicrobial activity of Sonneratia alba bark. The carbon tetrachloride, chloroform soluble partitionate of methanolic extract and crude methanolic extract showed significant antioxidant property using 1,1-diphenyl-2-pecrylhydrazyl(DPPH) scavenging assay ,of which chloroform partitionate and crude extract demonstrated highest activity with IC50 value of 12µg/ml and 14µg/ml respectively. In the brine shrimp lethality bioassay, LC50 values obtained from the best fit line slope were 0.812, 14.94, 0.831 and 3.288 µg/ml for standard (Vincristine sulphate), n-Hexane, carbon tetrachloride and chloroform soluble partitionate of methanolic extract respectively. The carbon tetrachloride soluble fraction revealed moderate activities against Bacillus cereus, Bacillus subtilis, Sarcina lutea, Pseudomonas aeruginosa and Shigella dysenteriae test organisms
Article Information
50
2233-2237
531KB
1652
English
IJPSR
Md. Ali Milon*, Md. Abdul Muhit , Durajan Goshwami , Mohammad Mehedi Masud and Bilkis Begum
Department of Clinical Pharmacy & Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
25 February, 2012
20 May, 2012
25 June, 2012
http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2233-37
01 July 2012
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