ANXIOLYTIC AND MOTOR COORDINATION ACTIVITY OF HUPERZINE-A IN RATSAbstract
The aim of the present study was to evaluate the anxiolytic effects and motor coordination activity of Huperzine-A in rats. Wistar rats were treated orally with Huperzine-A (0.5, 1, 2 & 4 mg/kg) and diazepam (2 mg/kg p.o) as a standard anxiolytic drug then exposed to Elevated plus Maze (EPM) and Light Dark Box (LDB). The effects of the Huperzine-A on motor coordination were evaluated by actophotometer test. The rats treated with Huperzine-A drug (2mg/kg and 4mg/kg) showed significant increase in the percentage of entries and time spent in open arms of EPM, which is thought to reflect anxiolytic-like effects. Furthermore, Huperzine-A extracts (1, 2 & 4 mg/kg) significantly increased the percentage of time spent and number of transitions in the Light box in LDB test, indicating the anxiolytic effects of the substance. This anxiolytic effect of the huperzine-A was comparable to that of the diazepam, taken as standard. Also the Huperzine-A (2 mg/kg and 4 mg/kg) showed significant alteration in motor coordination compared to that of normal control group of rat. The present study demonstrates that the drug Huperzine-A has anxiolytic activity. The drug might act as NMDA receptor antagonist.
K. Jaswinder *, R. Singh, P. Singh, J. Kaur and H. Kaur
G.H.G. Khalsa College of Pharmacy, Gurusar Sadhar, Dist. Ludhiana Punjab, India.
25 November, 2016
26 January, 2017
17 February, 2017
01 June, 2017