ANXIOLYTIC EFFECT OF ETHANOLIC EXTRACT OF FLOWERS OF CHRYSANTHEM INDICUM IN ALBINO MICEAbstract
Mental disorders are commonly occurring and often seriously impairing in many countries throughout the world. The total number of people suffering from anxiety or depression amount to 615 million, Close to 10% of the world’s population is affected. Chrysanthemum indicum is an ancient herbal medicine used as an anti-arthritic, anti-inflammatory and anti-anxiety in many Asian countries. The elevated plus-maze (EPM) and open field test has been most familiar tool in the investigation of the neurochemical transmission basis of anxiety, for testing anxiolytic drugs. The anxiolytic activities of Ethanolic and Chloroform extracts of Chrysanthemum indicum Linn flowers were evaluated using the elevated plus-maze (EPM) and Open field. The ethanolic extract results are suggestive of anxiolytic activity in dosages around 250 and 500 mg/kg, as expressed by elevation of the time spent on the open arms in the plus-maze; a decrease of freezing and increase of deambulation in the open field test.
D. Sheela *, V. Srinivasan and E. Sukumar
Department of Pharmacology, Saveetha Medical College and Hospital, Chennai, Tamilnadu, India.
02 December, 2016
06 February, 2017
02 May, 2017
01 June, 2017