APPLICATION OF SPRAY DRYING TECHNIQUE FOR PREPARATION AMORPHOUS SOLID DISPERSIONAbstract
As time passes more and more poorly water soluble drug are being discovered. Formulating these drugs in to amorphous solid dispersion is an effective strategy to deliver poorly water soluble drugs. Spray drying is one of common and a well-established manufacturing technique which can be used to formulate amorphous solid dispersions (ASDs). However, the spray drying is complex phenomenon and the spray drying process parameters yield the ASD with specific characteristics. Various diverse factors interact in an inter-dependent manner to determine the final product properties. This review discusses the basic background of spray drying, and various aspects of spray drying such as instrumentation, thermodynamics, drying kinetics, particle formation process and scale-up challenges are included. Recent advances in the spray-based drying techniques are mentioned along with some future avenues where major research is needed.
B. N. Phapale * and A. P. Patil
Macleods Pharmaceuticals Ltd. , Shantinagar, Andheri (E), Maharashtra, India.
20 September, 2016
23 December, 2016
08 January, 2017
01 April, 2017