AQUA DISTILLATION ENHANCES THE ANALGESIC AND ANTI-INFLAMMATORY PROPERTIES OF ROSA DAMASCENA MILL.; A PILOT STUDYAbstract
Rosa damascena Mill. also known as Damask rose, Persian rose or Gul-e-Muhammadi of Rosaceae family is an aromatic small plant cultivated all over the world for its visual beauty, fragrances and therapeutic potential. The plant is rich in tannins, flavonoids, glycosides, carboxylic acids and ascorbic acid. In addition to its aromatic properties, the plant possesses laxative, anti-oxidant, anti-bacterial, wound healing, skin health, cardiotonic, hypnotic and cough suppressant activities. The medicinal uses reported from this plant are of its methanolic, ethanolic or chloroformic extract and of its essential oil. This research is planned to investigate the analgesic and anti-inflammatory potential of aqua distillate of Rosa damascena Mill. flower in two different doses i.e. 250 mg/kg and 500 mg/kg using Hot Plate, Tail Flick and acetic acid induced paw-edema method. Also as recent studies reported that alcoholic extract of Rosa damascena possesses analgesic activity and aqueous extract does not, so this study also aimed to evaluate these activities after its distillation in aqueous medium.
M. Osama * and R. Ikram
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.
13 April, 2018
20 July, 2018
25 July, 2018
01 December, 2018