ASSESSMENT OF INTRAPERITONEAL TOXICITY OF X42 FRACTION OF TERMINALIA IVORENSIS (COMBRETACEAE) IN RATAbstract
The present work focuses to check the acute and sub-acute toxicity studies of X42 fraction of Terminalia ivorensis in rats. Materials and methods: The acute toxicity of the extract was evaluated in rats. The rats were administered intraperitoneally the fraction at the dose of 50, 100, 200 and 300 mg/kg bw and recorded general symptoms and mortality. For sub acute toxicity, the rats received intraperitoneally, normal saline (control), 2.5; 5.0 and 10.0 mg/kg of the extract for 28 days. Animals were observed for general behavioral and signs of abnormalities during the experiment duration. The last day, blood was taken for hematological and biochemical analysis. The liver, kidney, and heart tissues were weighed. Results: Acute toxicity study produced dose dependent mortality with median Lethal Dose (LD50) of 200 mg/kg. Repeated administration of fraction caused no mortality. There were no significant changes (p>0.05) observed in serum biochemical markers, hematological markers, body weight changed, relative organs weight when compared to control group. Conclusion: The results show that the extract of T. ivorensis is moderately toxic when given intraperitoneally.
H. V. Zaza ⃰ , I. O. Tra-Bi, B. N. Djyh, M. Zeine, K. Konan, A. M. D’alméida and J. D. N’guessan
Biochemical Pharmacodynamy Laboratory, Biosciences Department, Felix Houphouet Boigny University, Gagnoa, Abidjan, Ivory Coast.
27 April, 2017
23 August, 2017
17 September, 2017
01 January, 2018