BENZOTHIAZOLE DERIVATIVE: A REVIEW ON ITS PHARMACOLOGICAL IMPORTANCE TOWARDS SYNTHESIS OF LEADAbstract
Heterocyclic chemistry plays a very most important role in medicinal chemistry as well as in organic chemistry. Most of the drug molecule formed and possesses therapeutic activity due to the heterocyclic scaffold. A slight change in heterocyclic moiety leads to the major therapeutic change in the drug molecule. Benzothiazole can serve as a unique and versatile moiety for experimental drug design. Benzothiazole and its derivatives are the essential chemical compounds with tremendous application in research area especially in synthetic as well as in pharmaceutical chemistry because of its potent and significant pharmacological activities. As we know that benzothiazole is a combination of two rings six-membered and five-membered and it is also known that both rings are responsible for the therapeutic activity. The main objective of our study is to find what changes lead to a better corrective benzothiazole shift moiety. A well-known approach to design new drug-like molecules, which allows achieving new pharmacological profile, action, toxicity lowering, is the development of a combination of 2- aminobenzothiazoles with another heterocyclic ring. A literature search was conducted on the databases namely Science direct, and PubMed with the help of the combination of different keywords: “Benzothiazole,” “antimicrobial activity, anticancer, anti-diabetic, anthelmintic activity.” The search was customized by applying the appropriate filters to get the most relevant articles to meet the objective of this review article. There is a various number of research and review article present of benzothiazole derivative in case of different disease which concluded that the benzothiazole is one of the most important scaffolds for the treatment of various disease.
A. Srivastava *, A. P. Mishra, S. Chandra and A. Bajpai
Pranveer Singh Institute of Technology, Bhauti, Kanpur, Uttar Pradesh, India.
09 August 2018
04 March 2019
12 March 2019
01 April 2019