BIOAVALIBILITY ENHANCEMENT OF RESVERATROL USING SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM DEVELOPED APPLYING CENTRAL COMPOSITE DESIGNAbstract
The objective of current study was to develop self-nanoemulsifying drug delivery systems using long-chain triglycerides of resveratrol to enhance its bioavailability. Solubility studies performed in different lipids, surfactants and cosurfactants. Phase diagrams constructed to select areas of nanoemulsion. SNEDDS formulation optimized using 33 central composite design (CCD) considering lipid (X1), surfactant (X2) and co surfactant (X3) as critical variables and optimized formulation was located using overlay plot. The nanometer size and high values of zeta potential depicted non-coalescent nature of SNEDDS. Resulted SNEDDS formulation improved in vitro release followed by Hixson Crowell model with higher regression R2 value 0. 929. Thermodynamic stability studies ascertained stable formulation. Mean droplet size in selected nanocarrier was found to be 83.29 nm. The nanocarriers showed enhanced bioavailability in albino rabbits when compared to pure drug. The novel approach developed by selecting optimum blends of lipids, surfactants and cosurfactant using central composite design.
Monika *, R. Garg and S. Sardana
NIET, Pharmacy Institute, Knowledge Park 2, Plot 19, Greater Noida, Uttar Pradesh, India.
22 November, 2017
16 February, 2018
19 February, 2018
01 August, 2018