BIOFILM AND METTALO BETA-LACTAMASE PRODUCTION IN ASSOCIATION WITH SERUM RESISTANT ACTIVITY AMONG CLINICAL STRAINS OF PSEUDOMONAS AERUGINOSAAbstract
Biofilms are communities of bacteria that are append to a surface and play significant role in the persistence diligence of bacterial infections. Bacteria with a biofilm are more defiant to antibiotics compared with planktonic bacteria. Biofilm producing bacteria are able to take possession on medical devices such as catheters and implants. The incidence of Biofilm producing microorganism runs around 80% of infections. These kinds of infections are difficult to make a diagnosis and treat. The present investigation has been done to analyze the correlation of MDR Pseudomonas sp with production of Biofilm, MBL production and Serum resistant activity. 63 (12.6%) Pseudomonas isolates were incurred from a total of 500 clinical samples and were speciated based on both phenotypic and genotypic methods. Among the total isolates detected 56.2% were positive for both Biofilm production and Serum resistant activity. MBL productions were observed in 70.83% of the isolates. The significance of the result also relates that all the isolates expressed high MAR index values that confirm the association between the virulence and its drug resistant traits.
R. Pradeepraj, D. Jayarajan and M. C. Harish *
Department of Biotechnology, Thiruvalluvar University, Vellore, Tamil Nadu, India.
22 November 2019
14 January 2020
27 January 2020
01 February 2020