CASSIA TORA SEEDS EXTRACT REGULATES LIPID METABOLISM IN ALLOXAN INDUCED DIABETIC RATSAbstract
The hypolipidemic activity of Cassia tora (Chakvat, Chakunda) (Family: Caesalpiniaceae) seeds extract have been studied in alloxan-induced diabetic rats. In this model oral administration of seed extract (500 mg/kg bw.P.o.) for 15 days in diabetic-dyslipidemic rats exerted significant lipid lowering effect as assessed by the reversal of serum levels of total cholesterol, phospholipids, triglyceride, free fatty acids, protein and lipid peroxide. The decrease of lipids and apoprotein levels of Very Low Density Lipoprotein and Low Density Lipoprotein were followed by stimulation of plasma post-heparin lipolytic activity as well as lecithin cholesterol acyltransferase, hepatic superoxide dismutase, catalase, triglyceride lipase and lipoprotein lipase activities with increase in reduced glutathione. Lipid and apoprotein level of High Density Lipoprotein were also recovered partially on treatment with seeds extract. The results of the present study demonstrated antidyslipidemic and antioxidant activities in seed extract of C. tora which could be used in prevention of diabetic dyslipidemia and related complications. The hypolipidemic activity of Cassia tora seeds was compared with a standard drug glibenclamide (600 µg/ kg body wt/ day p.o.).
V. Kumar *, F. Mahdi , R. Singh, A. Ali Mahdi , K. Jawad , R. K. Singh and M. Singh
Department of Biochemistry , Era’s Lucknow Medical College & Hospital Lucknow, U.P., India
26 December, 2014
14 February, 2015
28 May, 2015
01 August, 2015