CHEMOMETRIC ANALYSIS OF PARACETAMOL AND METACLOPROMIDE IN BINARY DRUG COMBINATIONSAbstract
In this study, the stomach environment of paracetamol and metaclopramide active substances was prepared with the aid of chemometric method and UV spectrophotometer and their concentrations were measured at certain ratios. Spectra of these two active substances were observed separately in UV spectroscopy at different concentrations. Spectra of paracetamol and metaclopromide were observed by UV spectroscopy at certain ratios and concentrations. These observed spectra gave us an idea by using the chemometric method to generate numerical data indicating whether these two drugs should be used together. Absorbance and concentration values were used in Minitab and other chemometric programs to calculate estimated concentrations with PCR and PLS. In the first step, the synthetic mixtures including paracetamol and metaclopromide were prepared and absorbance values are obtained from spectrophotometry. The second step, in drug tablets (Parol and Metpamid) was calculated amounts for paracetamol and metaclopromide. Because of recovery and standard deviation were accomplished, this study encouraged us to applied for drug analysis.
G. P. Ertokuş* and M. Yildiz
Department of Chemistry, Faculty of Science and Art, Süleyman Demirel University, Isparta, Turkey.
06 June, 2017
17 August, 2017
29 August, 2017
01 March, 2018