COMPARATIVE ANTIANXIETY POTENTIAL OF EUPHORBIA NERIIFOLIA LINN. LEAVES AND EUPHORBIA HIRTA LINN. AERIAL PARTSAbstract
Euphorbia neriifolia and Euphorbia hirta have been traditionally used for relieving anxiety and other nervous disorders. The present study was designed to evaluate and compare the antianxiety activity of E. nerrifolia leaves and E. hirta aerial parts using elevated plus maze model. Petroleum ether (60-80°C), chloroform, ethanol and aqueous extracts of both the plants were prepared and evaluated for antianxiety activity. Chloroform extract of E. neriifolia and ethanol extract of E. hirta showed significant antianxiety activity at the dose of 200 and 400 mg/kg, respectively, comparable to that of diazepam (2 mg/kg). The study was extended to develop the TLC fingerprint profile of the two plants using CAMAG HPTLC system, and the relative percentage of the separated constituents was calculated from the area of peaks. Further, phytochemical screening of the bioactive chloroform extract of E. neriifolia showed the presence of flavonoids, steroids/terpenoids, phenols, and tannins while the bioactive ethanol extract of E. hirta tested positive for flavonoids and steroids/terpenoids.
Gulsheen, A. Kumar * and A. Sharma
University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, Punjab, India.
06 July 2018
04 September 2018
10 September 2018
01 March 2019