COMPARATIVE MOLECULAR DOCKING ANALYSIS OF FLAVONOID COMPONENT FROM LAUNAEA PROCUMBENS (ROXB.) AGAINST TYROSINE-PROTEIN KINASE FYNAbstract
Plants have been studied since ages for their therapeutic uses. In the earlier time, not much was known about the phytocompounds, but today the constituents of the different plants have been extracted and isolated for the use in the name of medicines or drugs. Flavonoid is one of the most characteristic classes’ of compounds in higher plants known to play several important roles including therapeutic uses in cancer treatment. The activation of oncogenes in the cancer cells can be regulated by the selective tyrosine kinases inhibitors, and therefore it can be considered as a promising approach for the targeted therapeutic development. Hence, in the present study, the authors tried to combine the knowledge of using plant Launaea procumbens in traditional medicine by analyzing and identifying the specific phytocompounds, especially flavonoids, and evaluating its anticancer potential. The scope of the present study is based on the aim to determine the possible use of plant Launaea procumbens in the field of therapeutics for cancer studies by performing in-silico docking analysis of isolated flavonoid compound on Tyrosine-protein kinase Fyn in comparison to Methotrexate, Imatinib, Clofarabine, and Daunorubicin. Based on the molecular drugs docking and binding affinities of the target proteins with an isolated flavonoid constituent from the plant, and its physicochemical detailing, it was found that the isolated flavonoid constituent has high possibilities to be an anticancer drug if utilized further with systematic approaches.
G. J. Mishra *, C. Prajapati, M. Patel and M. N. Reddy
Department of Biosciences, Bapalal Vaidya Botanical Research Centre, Veer Narmad South Gujarat University, Surat, Gujarat, India.
22 May 2018
26 September 2018
21 January 2019
01 February 2019