COMPARISON OF ANTIHELMINTHIC ACTIVITY BETWEEN BISARYL BENZYL PIPERAZINE AND BENZIMIDAZOLE LINKED PIPERAZINE DERIVATIVESAbstract
Helminthes infections are more common in poor countries where people suffer from poor health hygiene and sanitation, though there are lot of marketed drugs available for these disease but the interesting thing about antihelminthics is that they are either pypirazine or benzimidazole derivatives, so as medicinal chemist the attention will be drawn towards these different moieties which exert same biological action, in this present work five derivatives of piperazine were synthesized by conventional methods using two schemes, by scheme 1 three compounds were synthesized which were Bis benzyl derivatives of pierazine and by scheme 2 already prepared piperazine 2,5 di one was reacted with benzimidazole derivatives to yield finally two benzimidazole linked piperazine derivatavies and these two different classes of piperazine deiatives were screened for antihelminthic activity against Pheretima posthuma to compare their potency in context of calculating paralyzing and death time. Result showed that bis-benzyl derivatives possess to some extent better activity than that of benzimidazole linked piperazine derivatives.
B. Shrestha , J. Banerjee *, P. K. Yadav, A. K. Gupta, H. Khanal
Department of Pharmacy, Sunsari Technical College, Dharan Nepal.
18 October, 2015
16 December, 2015
16 January, 2016
01 April, 2016