CURRENT STATUS AND FUTURE PROSPECTS FOR TUBERCULOSISAbstract
Tuberculosis is declared to be an infectious disease of global emergency by WHO. Approximately one-third of the world’s population is infected with the tuberculosis. The lengthy and laborious current treatment of 6-9 months is associated with problems like patient noncompliance, multiple drug resistance and persistence of mycobacterium and significant toxicity of drugs. The increasing emergence of drug resistance of mycobacterium highlights an urgent need to develop novel therapeutic targets and agents that are not only effective against drug resistant bacteria but can also herald the persistent form of bacteria and thereby shorten the length of TB treatment. However, an approach towards understanding the physiological characteristics of the mycobacterium and designing of such novel therapeutic agents that are effective against drug resistance & persistent bacteria can bring about a revolution in the TB chemotherapy in near future.
Shruti Rawal, Richa Sood, Nipun Mahajan, Manju Sharma and Ajay Sharma*
Department of Chemistry, LSS, Lovely Professional University , Phagwara, Punjab., India
10 February, 2010
20 April, 2010
28 April, 2010
01 May, 2010