CYTOTOXIC EFFECT OF CRUDE EXTRACTS OF ACACIA NILOTICAAbstract
The cytotoxic effect of crude extracts (n-hehane, ethyl acetate and chloroform soluble fractions) of root of Acacia nilotica was observed by brine shrimp lethality bioassay. The LC50 values of n-hexane, ethyl acetate and chloroform soluble fraction found to be 1.956, 2.079 and 1.981 respectively indicating that the some of the compounds of the extract are biologically active. From this experiment, it was revelead that the test sample showed different response at different concentrations. The mortality rate of brine shrimp was found to be increased with the increased concentrations of sample, and a plot of log of concentration versus percent mortality on the graph produced an approximate linear correlation.
Fahad Hussain and Mohammad Musarraf Hussain*
Assistant Professor, Department of Pharmacy, Jagannath University, Dhaka-1100, Bangladesh
21 January, 2012
29 March, 2012
17 May, 2012
01 June, 2012