DENDRIMER MULTIFUNCTIONAL NANO-DEVICE: A REVIEWAbstract
A dendrimer is described as a macromolecule, which is characterized by its highly branched 3D structure that provides a high degree of surface functionality and versatility. The unique properties of dendrimers such as uniform size, high degree of branching, water solubility, multiagency, well-defined molecular weight and available internal cavities make them attractive for biological and drug-delivery applications. These artificial macromolecules may be synthesized to reach the size of nano objects having dimensions similar to proteins. Recently dendrimers have successfully proved themselves as promising nanocarriers for drug delivery because they can render drug molecules a greater water-solubility, bioavailability, and biocompatibility. These features have made their application in pharmaceutical, nanotechnology and medicinal chemistry particularly attractive. In addition Nanoparticle drug-delivery systems are the popular ones as are able to increase the selectivity and stability of therapeutic agents. However reticuloendothelial system (RES) Uptake, drug leakage, immunogenicity, hemolytic toxicity, cytotoxicity, hydrophobicity restrict the use of these nanostructures. These shortcomings are overcome by surface engineering the dendrimers. Commercialization of dendrimers is now forthcoming. The present review briefly describes about dendrimer synthesis, types of dendrimers with different functionalities, properties various importance and their potential applications in pharmaceutical and other different field.
Jay Prakash Bharti, S. K. Prajapati , Manoj K. Jaiswal and Rahul Deo Yadav
Research Scholar, Department of Pharmaceutics, Institute of Pharmacy, Bundelkhand University, Uttar Pradesh, India
10 February, 2011
02 July, 2011
13 July, 2011
01 August, 2011