DESIGN AND IN-VITRO EVALUATION OF TENOXICAM NANOGEL CONTAINING NOVEON POLYMERAbstract
The aim of present work is to design a Tenoxicam loaded nanogel for the anti-inflammatory and analgesic effect of prepared nanogel. Tenoxicam is one of the NSAIDs of oxicam class; it is very potent and useful for chronic use in rheumatoid arthritis and osteriostatis. The formulations of nanogel based materials have high drug loading capacity, biocompatibility, and biodegradability which are the key points to design a drug delivery system effectively. This research article is to succinctly describe the recent development of nanogel drug delivery system concerning drug loading and swelling of drug from nanogel. To change the mode of administration of Tenoxicam for increasing its pharmacological action we prepared Tenoxicam loaded nanogel which is prepared by modified emulsification-diffusion method by using swelled polymer like noveon polycarbophil AA-1. The formulated nanogel was evaluated for particle size, zeta potential, drug content, entrapment efficiency, in-vitro drug diffusion studies, in-vitro permeation studies.
S. S. Chopade
Department of Pharmaceutics, Tatyasaheb Kore College of Pharmacy, Warananagar, Panhala, Kolhapur, Maharashtra, India.
11 March 2019
15 July 2019
15 November 2019
01 December 2019