DEVELOPMENT AND CHARACTERIZATION OF BILAYERD TRANSDERMAL FILM OF DICLOFENAC DIETHYLAMINEAbstract
The aim of this research work was to develop and characterise bilayer film and to investigate its potential as slow-release wound healing vehicle. The bilayer is composed of an upper layer impregnated with Diclofenac diethyl amine and a drug-free lower layer, which acted as a rate-controlling membrane. Solvent casting technique was employed to prepare transdermal films. Pre formulation studies are performed to determine solubility, melting point, compatibility and partition coefficient. Alginate based bilayer film for wound healing was successfully developed. The in vitro drug release study implied that by using the bilayer films which retain the drug for a longer period of time thus minimise the dressing changing frequency. The method adopted in this research work is genuine can be used as routine analysis of the drug.
Potlapally Laxmi*, Azeez Mohammad and G. Shirisha
Department of Pharmaceutics, Venkateshwara Institute of Pharmaceutical Sciences, Cherlapally, Nalgonda-508001, Andhra Pradesh, India
08 October, 2013
15 February, 2014
03 May, 2014
01, June 2014