DEVELOPMENT AND CHARACTERIZATION OF MANNOSYLATED QUERCETIN LOADED LIPOSOMES FOR SKIN CARCINOMAAbstract
The solar UV radiation is the major trigger factor that causes skin cancer. Nearly 65% of cases of melanoma occurs dues to high exposure to the UV radiation. It also accounts for 90% of the nonmelanoma skin cancers also referred to as NMSC also including the cases of basal cell carcinoma (BCC) and the squamous cell carcinoma (SCC). The rate of malignancy in other cases has seemed to get reduced but this is not the situation in case of NMSC, which seemed to have increased and also affect people of younger ages. Cases of NMSC can be accounted for 15,000 deaths in the USA alone. This is surely one of the major health concerns of the nation also. In order to find a solution to this problem a new form of drug delivery system using the specific ligand that has receptor on the surface or the target cells is being proposed. The current discussion deals with the making of the mannosylated quercetin loaded liposomes that can be used for targeting cancerous cells. The methods of transmission electron microscopy (TEM) used for the surface morphology. The MTT assay was done against two different cell lines so that their cancer-preventive or curative properties can be assured. The research, hence establishes the fruitful development of Mannosylated Quercetin loaded liposomes (MA-QuLps) for the targeting of the skin cancer cells.
N. Verma and S. Saraf *
University Institute of Pharmacy, Pt. Ravishankar Shukla University Raipur, Chhattisgarh, India.
20 July 2019
24 September 2019
26 September 2019
01 October 2019