DEVELOPMENT AND CHARACTERIZATION OF MICROPARTICLES OF SUMATRIPTAN SUCCINATE CARRIER SYSTEM VIA NASAL ROUTEAbstract
Sumatriptan succinate is the 5H1 receptor agonist and used in the treatment of migraine, cluster headache. The main objective is to develop ideal anti-migraine nasal mucoadhesive microparticles as local and systemic drug delivery system. An attempt was made to formulate the nasal mucoadhesive microparticle of Sumatriptan succinate with excipients like mucoadhesive polymers i.e., HPMC, ethyl cellulose, etc., by using modified solvent evaporation method. And evaluated them for production yield, drug loading efficiency, surface morphology by SEM, drug content, particle size, in-vitro drug release studies. The release rates were studied using GraphPad Prism software. The prepared micro-particles of Sumatriptan succinate formulations were found to be satisfactory particle size i.e., in the range of 33.3 to 59.94 µm, mucoadhesion time of F5 found to be 321 min drug content was found to be 81.79 % to 89.16%, and drug release of the drug follows zero order kinetic model. Optimized formulation F5 shows that the developed formulations have shown improved dissolution profile in comparison to other formulation. The developed nasal mucoadhesive microparticles have the potential to deliver of anti-migraine drugs via the nasal route.
S. T. Galatage *, S. G. Killedar, A. B. Patil, A. A. Alman and S. S. Harale
Sant Gajanan Maharaj College of Pharmacy, Shivaji University, Mahagoan, Kolhapur, Maharastra, India.
13 December 2018
17 March 2019
28 March 2019
01 September 2019