DEVELOPMENT AND IN-VITRO EVALUATION OF CHLORHEXIDINE AND FLURBIPROFEN HARD CANDY LOZENGESAbstract
The mouth of human body provides non-shedding surfaces (teeth) for natural microbial colonization. This can result in the accumulation of large masses of bacteria and their products at stagnant sites. Dental plaque, Periodontitis and gingivitis are some of this type of conditions, which can develop due to microbial accumulation on teeth and Infections of throat leading to tonsillitis, pharyngitis, laryngitis, sour throat etc. Chlorhexidine is widely used antimicrobial drug in the treatment of dental plaque and gingivitis and Flurbiprofen is used as anti-inflammatory drug to reduce pain and inflammation. Lozenges are designed to deliver medications directly to the mucus membranes of the mouth and oropharengial cavity by dissolving slowly when placed between the tongue and gums. Lozenges provide maximum amount of local action thus Chlorhexidine and Flurbiprofen are formulated as lozenges to provide local antiseptic and anti-inflammatory action. The candy based lozenges were prepared by heat and congealing method by sugar as lozenge base, HPC, HPMC as polymers, citric acid artificial flavours and colours and other essential excipients. Some selected formulations were tested for drug excipient interactions subjecting to IR Spectral analysis. Formulated lozenges were evaluated for weight variation, crushing strength, friability, thickness, taste, dissolution time, and %assay. Crushing strength of optimized troches was found between 8-9.50 kg/cm2. The candies can provide an attractive alternative formulation in the alleviation of pain and Inflammation.
Renuka Pothu *, Adella Aparna and Y. Madhusudan Rao
Department of Pharmaceutics, Vaagdevi College of pharmacy , Kishanpura, Warangal, Telangana, India
18 December, 2014
25 April, 2015
15 July, 2015
01 August, 2015