DOCKING STUDIES OF GANODERMA LUCIDUMAbstract
Ganoderma is a miracle edible mushroom with unique composition and miraculous health benefits. The investigation aimed to elucidate interactions for the active compounds of Ganoderma lucidum namely Ganoderol A, Ganoderol B, Ganoderal A and Ganoderic Acid Y with Lanosterol 14 alpha demethylase enzyme using molecular docking software Arguslab. The effect of ganomycin1 and 2 as an inhibitor against HIV 1 protease and Tyrosinase were carried out using molecular docking software DOCK 6.3. The in-silico docking analysis of Ganoderma lucidum triterpenes was found to be effective as inhibitors of Lanosterol 14 alpha demethylase. The grid score and best scored conformations of Ganomycin 1 and 2 suggest that both have a significant inhibitory effect on these enzymes, comparable to the known inhibitors. The docking results showed significant inhibitory action of these compounds indicating the possibility that they can be used as potent drugs in the future. Thus these natural compounds have diverse structural and biological properties which can serve them to be utilized as a valuable lead molecule for the treatment of various diseases.
A. Gupte, A. Palande, S. Venkata and R. Pol *
School of Biotechnology and Bioinformatics, D. Y. Patil University, Mumbai, Maharashtra, India.
09 June, 2017
09 August, 2017
17 August, 2017
01 March, 2018