DOCKING, SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL QUINOLINE CONTAINING SCHIFF BASES FOR ANTI-INFLAMMATORY AND ANTI-OXIDANT ACTIVITIESAbstract
Quinolines bears a very good synthon so that a variety of novel heterocyclic with good pharmaceutical profile can be designed. There are various biological activities for quinolones such as antibacterial, antimalarial and various drugs possessing quinolone as nucleus are ciprofloxacin (Cipro), lomefloxacin (Maxaquin), norfloxacin (Noroxin), ofloxacin (Floxin), moxifloxacin (Avelox) and levofloxacin (Levaquin). So, in the present work 2-chloro quinoline 3-carbaldehyde containing quinolines were synthesized by using solvent conservation techniques like reflux technique. Various quinolines derivatives were synthesized by the condensation reaction between dimethylformamide, PoCl3, and different substituted aniline to give 2-chloro 3-carbaldehyde (1a). The reaction of 2-chloro 3- carbaldehyde with metformin gives quinolines Schiff bases as final compound (2a-2d). The obtained product was purified and structures were confirmed by TLC, MP & IR spectroscopy. All the compounds were screened for in-vitro anti-inflammatory activity using diclofenac sodium as standard by using protein denaturation method. Further, the selected compounds also studied for anti-inflammatory activity by in-vitro methods and anti-oxidant activity by hydrogen peroxide methods. Some of the compounds have shown significant activities compared to standard.
D. Mopuri, S. V. Syed * and A. Madhulatha
Department of Pharmaceutical Analysis, Acharya Nagarjuna University College of Pharmaceutical Sciences Guntur, Andhra Pradesh, India.
02 May 2019
22 August 2019
01 September 2019
01 February 2020