EFFECT OF ALOE VERA EXTRACT AND ISONIAZID – RIFAMPICIN DRUG ON LIVER HISTOLOGICAL STUDIES OF MALE WISTAR RATSAbstract
The study carried out to find the effect of Aloe vera extract on the toxicity induced by INH – RIF in male Wistar albino rats. We have perform the experiments on rats for 30 days and found the effect on histological alternations of liver by two different method. Firstly, by Compound microscopy and the same tissues were further process through SEM microscopy. We have found the effect of Aloe vera extract and isoniazid and rifampicin on histological architecture of liver. We found that there is partial restoration of hepatic function as evident from normalization of serum markers of liver function, and we were able to show hepatoprotection against INH+RIF induced hepatotoxicity, as evidenced by the partial reversal of increased serum transaminases showed trend towards returning to normal (but partially) by supplementation of Aloe vera indicating partial hepatoprotective effect. Co-administration of Aloe vera extract along with anti-tuberculosis drugs showed hepatoprotection in some extent against INH-RIF drugs.
G. V. Zodape * and P. P. Bhise
Departments of Zoology, S. S. and L. S. Patkar College of Arts and Science, V.P. Varde College of Commerce and Economics, Mumbai, Maharashtra, India.
23 January, 2018
16 April, 2018
11 June, 2018
01 October, 2018