EFFECT OF CO-PROCESS EXCIPIENTS IN FORMULATION OF ODTs USING A MODEL DRUGAbstract
Different types of excipients were compared, in terms of their effect in (oral disintegrated tablets-ODTs) to optimize drug delivery and manufacturability. Therefore, the influence of excipients on the quality of ODTs was investigated by formulating and evaluate ODTs using an equal dose of water-soluble Baclofen (B) and poorly water-soluble Meloxicam (M) as model drugs. ODTs of both drugs were prepared using nine different co-process excipients for (B1-B9) and (M1-M9) formula (Pharmaburst®, Ludiflash®, F-melt®, Prosolv HD 90®, Prosolv SMCC 5O®, Prosolv ODT G2®, ProsolvEASYtab SP®, ProsolvEASYtab Nutra®, Lactose microfine), respectively by direct compression method. The prepared ODTs were evaluated for their: drug content, weight variation, thickness, disintegration time, wetting time, hardness, friability, and in-vitro dissolution. Both B-ODTs and M-ODTs showed no significant difference in the results of ODTs evaluation, by Using Design Expert 10 to select the best formulae of both drugs the best formulae were for poor water-soluble M9 (Lactose) > M3 (F-melt) > M6 (pro ODT) > M1 (Ph.brust) and for water-soluble: B4(Pro HD 90) > B3 (F-melt) > B6 (Pro ODT) > B1 (Ph.brust) F-melt®, Prosolv ODT G2®, and Pharmaburst®500 co-processed excipients showed the best result of quality control test and performed with no significant difference between water soluble and poor water-soluble drug, made them highly recommended to be utilized in ODT formulation.
M. A. El-Nabarawi, R. A. Abd El-Monem and I. E. I. Al-Samadi *
Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Misr University for Science and Technology, Giza, Egypt.
31 August 2018
03 November 2018
09 November 2018
01 May 2019