EFFECT OF TRANS – ESTERIFICATION OF OIL ON NANOEMULSION GEL FOR TOPICAL DRUG DELIVERYAbstract
The research investigated the modification of nano-emulsion by using transesterfied soyabean oil, to enhanced solubility and diffusion of voriconazole. Ternary phase diagrams of soyabean oil, acid / base esters of soyabean oil, Tween 80: PEG 400 (S/CoS) and water were developed. Ester value of soyabean oil increased from 214.04 to 261.5mg KOH/1g for acid ester and 293.58mg KOH/1g for base ester confirmed transesterification. The modified nanoemulsion batches E4, E5, EA4, EA5, EB2 and EB3 showed thermodynamic stability. Nanoemulsion of Soyabean oil (E3 and E4), acid ester (EA4 and EA5), and base ester (EB2 and EB3) were selected for in-vitro drug diffusion studies. The globule size of batch E4, EA4 and EB2 nanoemulsion was found to be 185.6, 162.8 and 115.4 nm, respectively. Zeta potential of batch E4, EA4, and EB2 was observed -35, -27 and -9mV respectively. The in vitro release release profiles from the E4, EA4 and EB2 batches of nanoemulsion gel were fitted into Peppas kinetic model. Moreover, ‘n’ value of batch E4, EA4, and EB2 was 0.8844, 0.8284, 0.8475 non-fickian diffusion. The soyabean oil and soyabean acid ester oil nanoemulsion found to be stable and a promising vehicle to enhance the permeation of voriconazole for topical delivery.
A. A. Chikte, M. J. Umekar, M. N. Borkhade and N. S. Raut*
Department of Pharmaceutical Chemistry, Smt. Kishoritai Bhoyar, College of Pharmacy, Kamptee, Nagpur, Maharashtra, India.
20 May, 2017
22 July, 2017
25 July, 2017
01 February, 2018