EFFECTS OF SURFACTANT TYPE ON RETENTION OF BIOACTIVE COMPOUNDS OF SYZYGIUM AROMATICUM IN SPRAY DRIED LIPID BASED SYSTEMSAbstract
This work investigates the effects of the surfactant system used and of spray drying temperature in physicochemical properties and retention of bioactive compounds of lipid based systems loaded with bioactive compounds of Syzygium aromaticum. Seven formulations were prepared, containing Compritol 888 ato and buriti oil as lipids and maltodextrin DE10 as wall material. The surfactants Poloxamer 188, Gelucire 50/13 and Gelucire 50/2 were employed and classified by their hydrophilic-lipophilic balance (HLB). The emulsions were homogenized by means of an ultrasonic probe and spray dried. The eugenol and eugenyl acetate content of each formulation was quantified by HPLC before and after the spray drying process. Higher eugenol retention was obtained for the composition using the amphiphilic surfactant Gelucire 50/13® (HLB of 13). Retention of bioactive marker compounds was affected by spray drying temperatures. A higher spray drying temperature (140 °C) increased eugenol loss. The particle morphology was affected by the formulation composition and the drying temperature.
D. F. Cortés-Rojas, C. R. F. Souza and W. P. Oliveira*
Laboratory of R & D on Pharmaceutical Processes LAPROFAR”, School of Pharmaceutical Sciences of Ribeirão Preto, Brazil.
19 April, 2017
14 July, 2017
25 July, 2017
01 December, 2017