ENHANCEMENT OF POOR ORAL ABSORPTION DRUG VIA LIPID FORMULATION: SELF EMULSIFYING DRUG DELIVERY SYSTEMAbstract
The oral route of drug administration is one of the simplest route of drug administration throughout the world because its patients convenience. The drug administered through orally should possess good aqueous solubility for better oral absorption and thus bioavailability will increase. But it was found that 30-40% of the drug shows low solubility thus bioavailability profile will be affected. Self-emulsifying drug delivery (SEDDS) system is a novel therapeutic drug delivery system of those new drugs whose aqueous solubility is very poor. Thus, by this delivery system the new drugs can be administered to the body via oral route and hence therapeutic effect will be desired appropriately. The most unique feature of this delivery system can form oil in water emulsion when diluted in an aqueous phase. Thus, this delivery system enhances the rate and extent of drug or absorption when given by oral route. The cost of this delivery system is affordable as it can consist natural oil and common excipients. Thus, large scale production is also possible for manufacturing unit. In this review we discussed the nature of oils or lipids, surfactant and what should be the criteria for drug selection and also has been discussed the preparation and characterization of self-emulsifying drug delivery systems and their application in modern pharmaceutical dosage form.
S. B. Gavhane, S. Mantry *, S. A. Joshi, G. Y. Dama and S. Mohanto
Department of Pharmaceutics, SGMSPM’s Sharadchandra Pawar College of Pharmacy, Pune, Maharashtra, India.
28 May 2019
03 October 2019
09 November 2019
01 March 2020