ESTIMATION, RECOVERY STUDY & ASSAY OF MARKETED DOSAGE FORM OF BUPROPION HYDROCHLORIDE THROUGH DERIVATIVE SPECTROSCOPIC METHODAbstract
Depression is the most common and spreadable disorder in recent age as people are going through a lot of pressure in their daily work caliber and so many unconditional events. A new approach called derivatization spectroscopy was developed for the anti-depressant agent, marketed formulation of Bupropion hydrochloride, to confirm the interfering substances from the excipients of solid dosage form, in addition to that the stability parameters to assure the analysis time with the minimum usage of the reference standard and sample solution. The present work aims to develop simple, sensitive stability indicating the method to develop a model to estimate BPH in the solid dosage form by using derivative spectroscopy tool to avoid the excipients interferences in the developed assay method. First, made the stock solution of 100 µg/ml from 1000 µg/ml previously prepared solution. The method was validated over the concentration range of 5-50 µg/ml of marketed formulation of Bupropion Hydrochloride. The assay method & derivatization was performed using UV spectroscopy at 252 nm wavelength. The intra-assay & intermediate precision performed with the % RSD of less than 2.0%.
S. Maji and M. R. Jeyaprakash *
Department of Pharmaceutical Analysis, JSS College of Pharmacy JSS Academy of Higher Education and Research, Ooty, Tamil Nadu, India.
01 March 2019
23 June 2019
14 July 2019
01 December 2019