EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF TILIACORA ACUMINATA EXTRACT IN RATSAbstract
Inflammation is part of the body’s immune response. There can be four primary indicators of inflammation: pain, redness, heat or warmness and swelling. Plants have the ability to synthesize a wide verity of phytochemical compounds as secondary metabolites which shows anti-inflammatory activity. The anti-inflammatory activity of ethanol extract of Tiliacora acuminata stem and leaf was evaluated using the carrageenan-induced rat paw edema. The ethanol extract of stem and leaf of Tiliacora acuminata was injected at different doses such as 200 and 400 µg/kg body weights, and the study was compared with standard drug indomethacin (10 mg/ml). In rat paw edema model induced by carageenan the extracts were found to reduce similarly (p<0.001). The formation of edema at the 400 µg/ml dose level and showed 77.92% for stem and 84.37% for leaf respectively, inhibition of edema volume at the end of 3 h. These results suggest that Tiliacora acuminata has anti-inflammatory property comparable with those of standard drug and may be useful for the treatment of painful inflammatory condition.
A. Rajesh, A. Doss, P. S. Tresina and V. R. Mohan *
Department of Biomedical Sciences and Technology, Noorul Islam Center for Higher Education, Kumaracoil, Tamil Nadu, India.
31 January 2019
21 August 2019
03 September 2019
01 October 2019