EVALUATION OF ANTICONVULSANT ACTIVITY OF HIBISCUS ROSA SINESIS FLOWER EXTRACTSAbstract
Objective of the study was to assess the anticonvulsant activity of extracts of Hibiscus rosa sinesis in albino rats. Methods: The anticonvulsant activity of extracts of flowers of Hibiscus rosa sinesis in rats were assessed using maximum electroshock seizure (MES) test and isoniazid (INH) using albino rats. The time taken before the onset of clonic convulsions, the duration of colonic convulsions and mortality protection were recorded. Results: The alcoholic extract of Hibiscus rosa sinesis flowers decreased the duration of hindlimb extension; clonus and stupor phase of MES induced convulsions as compared to control. However, all the extracts of flowers of Hibiscus rosa sinesis Linn. did not show any significant anticonvulsant activity against INH induced seizures. Conclusion: The alcoholic extract of Hibiscus rosa sinesis inhibits MES -induced convulsions but not INH-induced convulsions in animal models.
Anoop Singh *, I. C. Giri, Namrata Saxena, M. I. Shaikh R. B. , Birari and Ajay Singh
Dr. M. C. Saxena College of Pharmacy, Lucknow (UP), India
28 February, 2010
15 April, 2010
25 April, 2010
01 May, 2010