EVALUATION OF THE EFFECT OF TYLOSIN (MACROLIDE ANTIBIOTICS) ON MURINE TOXOPLASMOSISAbstract
Toxoplasmosis is a parasitic disease with global prevalence that is caused by a unicellular organism called Toxoplasma gondii. Given the high prevalence of the disease in the country, particularly in pregnant women, and severe complications of the disease for the fetus, congenital type, the disease consequences for patients taking medications that suppress the immune system as well as side effects caused by common treatment methods, discovery of new drugs with minimal side effects seems to be necessary. In this study was an attempt to investigate the effect of tylosin on toxoplasma in-vivo environment. 200000 parasites (tachyzoite form) were subcutaneously injected to 60 Balb/C mice that were divided into 6 groups (each consisting of 10 samples). Tylosin with four different concentration levels (10-80 mg/kg) was intraperitoneally injected. One of the groups was tested without injection of medicine and another group was tested with sulfadiazine and the disease process was carefully investigated in these groups. Comparison of treatment groups with the control group and statistical analysis of data showed a significant difference in the results obtained from the use of tylosin in the groups and it was observed that the effect of tylosin on the T. gondii is dose dependent. Also any increase in the drug dose up to 80 mg/kg prolonged the survival time in the mice. The results showed that there was a significant difference between the drug dosage and the average survival time in the mice infected with T. gondii. Therefore, this drug has proved to be effective in treatment of infected mice.
Q. Asgari, M. F. Madan, S. Alipour * and S. N. Shahabadi
Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
09 October, 2017
11 March, 2018
18 March, 2018
01 July, 2018