EVALUATION OF THE WOUND HEALING PROPERTIES OF MIMOSA PUDICA LINN. IN STREPTOZOTOCIN-INDUCED DIABETES MELLITUS IN RATSAbstract
Mimosa pudica Linn. (Fabaceae) It is traditionally used to treat wounds and diabetes mellitus. The study was designed to evaluate the wound healing properties of ethyl acetate and ethanolic extracts of seeds of Mimosa pudica in streptozotocin-induced diabetes mellitus in rats at dose levels of 100, 200 and 400 mg/kg body weight. Both extracts decrease the fasting blood glucose in a dose-dependent manner. A significant decrease in blood glucose level was also observed in the ethanol and ethyl acetate extract treated rats at different dose levels. The maximum percentage contraction in wound area (25.52 to 97.37, 23.65 to 93.12) was observed in diabetic rats treated with ethanolic extract at 400 mg/kg and 200 mg/kg dose respectively and with a significant percentage contraction in wound area (21.34 to 96.87, 20.71 to 95.22) was observed in diabetic rats treated with ethyl acetate extract at 400 mg/kg and 200 mg/kg dose respectively on 15th day. The results exhibit that Mimosa pudica possesses considerable antidiabetic and wound healing activity in diabetic rats.