FORMULATION AND EVALUATION OF ALLYLESTRENOL IMMEDIATE RELEASE TABLETSAbstract
Among the different routes of administration, the oral route of administration continues to be the most preferred route due to various advantages including ease of ingestion, avoidance of pain, versatility and most importantly patient compliance. The different dosage forms include tablets and capsules. Recently immediate release tablets have started gaining popularity and acceptance as a drug delivery system, mainly because they are easy to administer and lead to better patient compliance. The present work involves the formulation development, optimization and in-vitro evaluation of immediate release allylestrenol tablets. To minimize critical process parameters and since allylestrenol is heat sensitive, direct compression method was selected for the formulation of immediate release allylestrenol tablets. Tablets were prepared using cross carmellose sodium, crosspovidone, pre gelatinized starch and sodium starch glycolate as disintegrants. During the course of study it was found that the formula G4 containing sodium starch glycolate as disintegrant exhibited acceptable disintegration time, percentage drug content per tablet and in vitro drug release. So at last it was concluded that immediate release allylestrenol tablets can be prepared using direct compression which met the required specifications.
Bishwajit Bokshi and Aparajita Malakar*
Pharmacy Discipline, Life Science School, Khulna University, Khulna-9208, Bangladesh
02 February, 2012
27 May, 2012
29 May, 2012
01 June, 2012