FORMULATION AND EVALUATION OF CETUXIMAB LOADED POLYMERIC NANOPARTICLESAbstract
Nanoparticles speak to one of the appealing choices in the compelling treatment of tumor chemo-treatment. In the present work, definition, and improvement of a novel Cetuximab (MTX)- stacked biodegradable nanoparticles utilizing poly(D, L-lactide-co-glycolide) (PLGA) was done. Nanoparticles stacked with anticancer operators can effectively build sedate focus in malignancy tissues and furthermore act at the cell level, improving antitumor viability. These medication conveyance frameworks enhance bioavailability by improving fluid solvency, expanding protection time in the body and focusing on medication to a particular area in the body. The arranged nanoparticles were assessed for physicochemical properties, for example, molecule measure, zeta potential, discharge thinks about, and so forth. Molecule size of the upgraded definition was < 200 nm. Our essential outcomes exhibit that the created Cetuximab-stacked PLGA nanoparticles are discharging the medication for the delayed timeframe. The goal behind the work is to contemplate the impact of definition factors on the molecule estimate, sedate exemplification and % aggregate medication arrival of nanoparticles.
A. Kaushik * and H. K. Sharma
Sri Satya Sai University of Technology & Medical Sciences, Pachama, Sehore, Madhya Pradesh, India.
12 May 2018
30 June 2018
06 July 2018
01 January 2019