FORMULATION AND EVALUATION OF ENTERIC COATED ASPIRIN TABLET BY USING BIOEPOXY RESIN AS COATING MATERIALAbstract
An enteric coating is a polymer barrier applied to oral tablets; it prevents dissolution and disintegration of tablet in the gastric environment. Some drugs like aspirin that have an irritant effect on the GI Track after administration, can be prepared as enteric-coated tablet. Aspirin is used to reduce fever and to relieve pain from various conditions. By coating aspirin tablet with polymer it prevents the stomach bleeding. Novel biodegradable epoxy resins having special properties like dissolution in alkaline solution but remain intact in acidic solutions. It is biodegradable, biocompatible, made from 100% bio-based content, non-toxic in nature. Owing to these above advantages we have used bio epoxy resin for coating on aspirin table and tested its performance at various conditions. Coated tablets are found resistant to gastric pH and percentage drug release after 90 min was found 48%. The performance data was compared with various commercial brands available in the market. Coating aspirin tablet with bio epoxy resin is a safe alternative.
S. S. Tiwari *, S. J. Wadher and O. S. Yemul
Department of Pharmaceutics, School of Pharmacy, Swami Ramanand Teerth Marathwada University, Nanded, Maharashtra, India.
30 January 2019
16 June 2019
24 September 2019
01 October 2019