FORMULATION AND EVALUATION OF LORNOXICAM MOUTH DISSOLVING TABLET BY USING NATURAL SUPERDISINTEGRANTSAbstract
The concept of fast dissolving drug delivery system emerged from the desire to provide patients with more convenient means of taking their medication. It is difficult for many patients to swallow tablets and hard gelatin capsules. The main objective of the study is to develop a reproducible formulation of fast dissolving tablets of Lornoxicam already used the therapeutic molecule to enhance effectiveness and to avoid side effects (gastric irritation) of the drug. Different batches of tablets were prepared by direct compression method using a different concentration of superdisintegrants like gum karaya, chitosan, and fenugreek seed mucilage powder. Before compression pre-formulation studies were done which includes characterization of the blend and physical compatibility studies with excipients. Effect of change in super disintegrant and their concentration on the formulation was studied. Final batches were compared for the superiority of superdisintegrants in the formulation of MDT of Lornoxicam. Tablets were evaluated for weight variation, thickness, hardness, friability, drug content, in-vitro disintegrating time and in-vitro drug release.
N. V. Misal * and S. Z. Chemate
Department of Pharmaceutics, Dr. V.V.P.F’s College of Pharmacy (Savitribai Phule Pune University), Ahmednagar, Maharashtra, India.
31 July 2018
09 October 2018
16 October 2018
01 April 2019