FORMULATION AND EVALUATION OF MUCOADHESIVE BUCCAL TABLETS OF PROPRANOLOL PREPARED USING NATURAL POLYMERAbstract
Propranolol is beta-blocker and it is widely used in the management of hypertension. Propranolol is used to treat tremors angina, hypertension, heart rhythm disorder and other heart or circulatory conditions. The mucoadhesive buccal tablets of propranolol were papered by wet granulation method using natural polymer like Vigna mungo powder. The compatibility studies of drug and excipient were performed by FT- IR spectroscopy and DSC. After examining the flow properties of the powder blends the results were found to be within prescribed limits and indicated good flowing property, hence it was subjected to compression. The tablets were evaluated for post-compression parameters like weight variation, hardness, thickness, friability, drug content uniformity, surface pH, in-vitro studies like swelling, mucoadhesive strength, residence time and drug release. Formulation (F6) containing Vigna mungo showed good muco-adhesive strength (21.75g) and maximum drug release of 89.31% in 12 h and residence time (6.9 h). The drug content shown 92.19%, surface pH was found to be 6.9. All the evaluation parameters given the positive result and comply with the standards. The results indicated that the mucoadhesive buccal tablets of propranolol may be good choice to bypass the extensive hepatic first pass metabolism with an improvement in bioavailability of propranolol through buccal mucosa.
G. M. Milind *, G. Yogesh and A. Yadav
Department of Pharmaceutics, Gourishankar Institute of Pharma-ceutical Education and Research, Limb Satara, Maharashtra, India.
10 October, 2017
20 December, 2017
04 March, 2018
01 July, 2018