FORMULATION AND EVALUATION OF MUCOADHESIVE IN-SITU NASAL GEL OF CYCLOBENZAPRINE HYDROCHLORIDEAbstract
Cyclobenzaprine hydrochloride (CBZ) is a muscle relaxant. It has 33% bioavailability due to its first pass effect and hence posses problems in the development of oral sustained release formulations. Mucoadhesive thermo reversible in-situ nasal gel of Cyclobenzaprine HCl was designed and developed to sustain its release due to the increased nasal residence time of the formulation. Poloxamer 407 (PF 127) was selected as it has excellent thermo sensitive gelling properties. HPMCK4M was added to impart mucoadhesive to the formulation, and PEG 400 was used to enhance the drug release. 32 Factorial designs were employed to assess the effect of concentration of HPMCK4M and PEG 400 on the performance of in-situ nasal gel systematically and to optimize the formulation. An optimized in-situ nasal gel was evaluated for appearance, pH, drug content, gelation temperature, mucoadhesive force, viscosity and ex-vivo permeability of drug through nasal mucosa of a goat. Additionally, this formulation was proved to be safe as histopathological studies revealed no deleterious effect on nasal mucosa of a goat after prolonged exposure of 21 days to the optimized formulation. Thus the release of Cyclobenzaprine HCl can be sustained if formulated in an in-situ nasal gel containing poloxamer 407 to achieve its prolonged action.
R. K. Jani *, P. Rana and R. S. Baldha
Department of Pharmaceutics, Parul Institute of Pharmacy and Research, Parul University, Limda, Vadodara, Gujarat, India.
02 August 2018
20 November 2018
28 March 2019
01 April 2019