FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF METFORMIN HYDROCHLORIDE USING AGAR AS NATURAL SUPER DISINTEGRANTAbstract
The objective of the present work is to develop orodispersible tablets of Metformin hydrochloride using agar as natural super disintegrant to improve bioavailability, disintegration time, dissolution efficacy and patient compliance. Fast dissolving drug delivery system has numerous advantages over conventional dosage form like tablet, capsule, syrups etc. Formulation of nine batches out of which batch F5 with 6% super disintegrant was found to have better results in compare to other formulations, the F5 batch was passed with friability test and found negligible loss (0.4%), Then the batch was further evaluated for disintegration test and found to have 11.03 sec and in-vitro dispersion was found to be 15 sec in simulated saliva fluid and percentage drug release was evaluated to be 98.5% in less than 30 min. Hence, F5 batch was found to be better as it contain 6% treated agar. It shows further potential to carry animal model.
P. Bhardwaj * and S. B. Chauhan
Department of Pharmaceutics, Amity University, Sector - 125, Noida, Uttar Pradesh, India.
05 January, 2018
12 September, 2018
17 September, 2018
01 October, 2018