FORMULATION AND EVALUATION OF pH TRIGGERED IN-SITU OCULAR GEL OF OFLOXACINAbstract
Rapid precorneal elimination of the drug in conventional ophthalmic solution leads to poor bioavailability and less therapeutic response, which can be overcome by the use of in-situ gel forming system that is instilled into the eye and undergoes a sol-gel transition in the cul-de-sac. The aim of the present study was to formulate and evaluate pH-triggered in-situ gels for ophthalmic delivery of ofloxacin. Ofloxacin ophthalmic solution is commonly used in the treatment of bacterial eye infection. The in-situ gelling systems were prepared by using different concentrations of carbopol 934 as a gelling agent in combination with hydroxypropyl methylcellulose (HPMC) E15LV as a viscosity enhancing agent. The prepared formulations were then evaluated for visual appearance, clarity, pH measurement, gelling capacity, rheological studies, and drug content. The developed formulation was therapeutically efficacious and stable. Thus the developed system can be used as a viable alternative to conventional eye drops.
K. Wadhwa *, C. Sharma, M. Goswami and N. Thakur
University Institute of Pharma Sciences, Chandigarh University, Gharuan, Mohali, Punjab, India.
17 January 2019
17 April 2019
13 June 2019
01 October 2019