FORMULATION AND EVALUATION OF SPHERICAL CRYSTALS OF INDOMETHACIN FOR THE IMPROVEMENT OF SOLUBILITY AND MICROMERITIC PROPERTIESAbstract
Indomethacin, an anti-inflammatory drug, exhibits poor water solubility and flow properties. Spherical agglomerates were prepared by crystallo-co agglomeration technique. Crystallization medium used for spherical agglomerates of Indomethacin consisted of acetone (good solvent); water (poor solvent); dichloromethane (bridging liquid). HPMC, PVP and PEG6000 this polymer were used in the agglomeration process. Spherical agglomerates were characterized by DSC, IR, XRD, and SEM. Micromeritic, dissolution behavior and compression studies were carried out. For optimization study Box Behnken Design used. Heckle plot studies showed low mean yield pressure and a low value indicating excellent compressibility and compatibility of agglomerates. Process variables such as an amount of bridging liquid, stirring speed and polymer ratio were optimized. The dissolution profile of the spherical agglomerates was compared with pure Indomethacin. Spherical agglomerates exhibited decreased crystallinity and improved micromeritic properties. The dissolution of the spherical agglomerates was improved compared with pure Indomethacin sample.
P. V. Kamble and F. J. Sayyad *
Department of Pharmacognosy and Phytochemistry, Government College of Pharmacy, Karad, Satara, Maharashtra, India.
12 February 2019
20 March 2019
26 March 2019
01 April 2019