FORMULATION AND IN-VITRO EVALUATION OF ACECLOFENAC ORODISPERSIBLE TABLETSAbstract
The object of the study was to formulate and evaluate Aceclofenac orodispersible tablets (ODT) by wet granulation method using different super disintegrants in different concentrations. Orodispersible tablets produce rapid dissolution of drug and absorption thereby producing rapid onset of action. Five batches (AFD1, AFD2, AFD3, AFD4, AFD5) of Aceclofenac orodispersible tablets were prepared and characterized for hardness, friability, thickness, uniformity of weight, drug content, disintegration time, In-vitro dissolution studies. Formulation (AFD5) was found to be better formulation in terms of rapid disintegration and maximum percentage of drug release compared to other formulations.
S. Dharani*, K. Ramesh kumar, k. Elango, S. Hemalatha, P. Stephen and I. Nishanth
Department of Pharmaceutics, College of Pharmacy, Madras Medical College, Chennai-600003, Tamil Nadu, India
20 September, 2012
31 October, 2012
22 December, 2012
01 January, 2013