HEPATOPROTECTIVE ACTIVITY OF SACHHARUM OFFICINARUM AGAINST PARACETAMOL INDUCED HEPATOTOXICITY IN RATSAbstract
The hepatoprotective activity of juice of Saccharum officinarum was investigated against paracetamol (acetaminophen) induced liver damage in rats. Paracetamol (PCM) is analgesic, antipyretics drugs available as an over the counter (OTC) medication which cause hepatotoxicity as higher doses. Paracetamol at 3gm/kg induced liver damage in rats manifested by statically increased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphates (ALP), total and direct billirubin. The antioxidant parameter malondialdehyde (MDA) level was increase and reduced glutathione (GHS), total protein (TP) level were decrease. The physical parameter of liver weight and volume also increase. Histopatholgical and in vitro (% of cell viability) studies of the experimental animals were also done. The results indicate that the juice of Saccharum officinarum protects against PCM-induced hepatotoxicity presumably via antioxidant action.
B. A. Patel*, J. D. Patel and B. P. Raval
K. J. College of Pharmacy, Vadasma, Mehsana, Gujarat, India
26 January, 2010
13 March, 2010
22 March, 2010
01 April, 2010